Centre Mission

Mission

To develop advanced computational and modeling methodologies for analyzing complex biological data;

To build a central wet lab facility for mammalian cell and microbiology experimentation;

To initiate and assist collaborations on systems biology research and applications.

Current Research Projects

Projects

Differential regulations of Bcl-2 network in anti-mitotic drug induced mitotic arrest.

Cell-cycle and cell-type dependence of Bcl-2 network dynamics profiled by mitochondrial proteomics.

Dynamics of p53 pathway in deciding cell fate of senescence or apoptosis in response to different DNA damaging reagents.

Structure-dynamics-function relationships in large-scale complex brain networks.

Population level modeling of bacteria growth and migration inside a tumor and its effect on tumor growth.

Experimental and theoretical study of osmostress response through the Hog pathway in yeast.

Statistical mechanical study of noise propagation in molecular networks.

Bioinformatics study of synergistic gene regulation and regulatory hierarchy in yeast.