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SHI, Jue

Contact: Rm. T922, Hong Kong Baptist University
Tel: (852) 3411-7037


Email: jshi@hkbu.edu.hk

 

Dr Jade Shi received her bachelor degree in physics at Zhongshan University in 1999. She went on to pursue her Ph.D. study in biophysics at the University of Michigan, Ann Arbor and was awarded the degree in 2006. She then conducted her postdoctoral work in Tim Mitchison's lab in the Department of Systems Biology at Harvard Medical School. She is now an Associate professor in the Department of Physics and Department of Biology (affiliated), Hong Kong Baptist University and also the Director of the Center for Quantitative Systems Biology.

 

Current Research Interests
Selected Publications
 
Current Research Interests

My main research interest is to develop new and more effective cancer therapeutics and treatment strategies by understanding the quantitative mechanisms underlying variation in anticancer drug response in distinct cancer types as well as immune-cancer interactions that modulate various aspects of oncogenesis, metastasis and treatment response. My lab combines quantitative single-cell imaging, ensemble profiling and computational modeling of cellular pathway/network dynamics to uncover novel drug targets, new drug candidates, new immuno-oncology therapeutics and improved combinatorial strategies for cancer treatment. More broadly speaking, my lab aims to answer the fundamental question of how dynamics of signaling molecules and their associated networks/pathways control differential cellular response to specific environmental signals and stress stimuli, and apply the acquired mechanistic understanding to guide development of more effective cancer treatment.

Examples of current research projects include, but not limited to, the following:

1. Dynamics of anticancer drug response using novel 3D cancer organoid and spheroid models;

2. Cytototoxic dynamics of Natural killer cells against distinct cancer targets;

3. Development of new immuno-oncology drug and drug target through profiling immunomodulating traditional Chinese medicine.


Department of Physics, Hong Kong Baptist University