Center for Quantitative Systems Biology

SHI, Jue

Contact: Rm. T922, Hong Kong Baptist University
Tel: (852) 3411-7037

Dr Jade Shi received her bachelor degree in physics at Zhongshan University in 1999. She went on to pursue her Ph.D. study in biophysics at the University of Michigan, Ann Arbor and was awarded the degree in 2006. She then conducted her postdoctoral work in Tim Mitchison's lab in the Department of Systems Biology at Harvard Medical School. She is now an assistant professor in the Department of Physics, Hong Kong Baptist University and also the associate director of the Center for Quantitative Systems Biology.

Current Research Interests

Selected Publications

1. Choi M+, Shi J+, Zhu Y, Yang R, Cho K. (2017) Network dynamics-based stratification of cancer panel for systemic prediction of anticancer drug response. Nature Communications, 8(1), 1940. (+: co-first author)
2. Shi J*, Mitchison TJ. (2017) Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic. Endocr Relat Cancer. 24(9): T83-T96.
3. Zhu Y, Huang B, Shi J*. (2016) Fas ligand and lytic granule differentially control cytotoxic dynamics of Natural Killer cell against cancer target. Oncotarget. 7(30):47163-72.
4. Kueh HY, Zhu Y, Shi J*. (2016) A simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics. Sci Rep., 6: 36585.
5. Zhu Y, Zhou Y, Shi J*. (2014) Post-slippage multinucleation renders cytotoxic variation in anti-mitotic drugs that target the microtubules or mitotic spindle. Cell Cycle. 13(11):1756-64.
6. Chen X, Chen J, Gan S, Guan H, Zhou Y, Ouyang Q, Shi J*. (2013) DNA damage strength modulates a bimodal switch of p53 dynamics for cell fate control. BMC Biol. 11(1): 73.
7. Liang J, Mok AW, Zhu Y, Shi J*. (2013) Resonance versus linear responses to alternating electric fields induce mechanistically distinct mammalian cell death. Bioelectrochemistry. 94C: 61-68.
8. Peng Q, Cai H, Sun X, Li X, Mo Z, Shi J*. (2013) Alocasia cucullata exhibits strong antitumor effect in vivo by activating antitumor immunity. PLoS ONE. 8(9): e75328.
9. Choi M⁺, Shi J⁺, Jung SH, Chen X, Cho K. (2012) Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage. Sci. Signal. 5, ra83. (+: co-first author)
10. Shi J*, Zhou Y, Huang HC, Mitchison TJ. (2011) Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res. 71(13): 4518-26.
11. Huang HC, Mitchison TJ, Shi J*. (2010) Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. PLoS ONE. 5(12): e15724.
12. Huang HC, Shi J, Orth JD, Mitchison TJ. (2009) Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 16(4): 347-58.
13. Shi J*, Orth JD, Mitchison T. (2008) Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 68(9): 3269-76.
14. Shi J, Dertouzos J, Gafni A, Steel D and Palfey BA. (2006) Single molecule kinetics reveals new signatures of half-sites reactivity in dihydroorotate dehydrogenase A catalysis. Proc Natl Acad Sci USA. 103(15): 5775-80.
15. Shi J, Palfey BA, Dertouzos J, Jensen KF, Gafni A and Steel D. (2004) Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics. J. Am. Chem. Soc. 126 (22): 6914-6922.

(*: corresponding author)