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18 May

2021

Distinguished Lectures by Dr Tony Hui

Online via Zoom

11:00am - 12:00pm

Quantitative Flux Analysis of Energy Metabolism

Speaker: Dr Tony Hui
Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health

Date: May 18, 2021 (Tuesday)
Time: 11:00-12:00 a.m. GMT+8 (Hong Kong Time)

Online via Zoom
(Meeting ID: 945 6859 0727)

Abstract:

Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine the direct sources of circulating nutrients, their interconversion rates, and eventual tissue-specific contributions to TCA cycle metabolism. Experiments with fifteen nutrient tracers enabled extensive accounting for both circulatory metabolic cycles and tissue TCA inputs, across fed and fasted mice on either high-carbohydrate or ketogenic diet. We find that glucose feeds the TCA cycle via circulating lactate. A majority of circulating carbon flux is carried by two major cycles: glucose-lactate and triglyceride-glycerol-fatty acid. Futile cycling through these pathways is prominent when dietary content of the associated nutrients is low, rendering internal metabolic activity robust to food choice. The presented in vivo flux quantification methods are broadly applicable to different physiological and disease states.

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29 Dec

2021

Book Launch: Everyday Physics - Colors, Light and Optical Illusions by Prof Michel A. Van Hove Cover Image

Book Launch: Everyday Physics - Colors, Light and Optical Illusions by Prof Michel A. Van Hove

Multi-purpose room, Level 2, Au Shue Hung Memorial Library, HKBU Limited to 30 attendees ; Public is welcome to join via Zoom

02:30pm - 04:00pm

This event celebrates the launch of Prof Van Hove's new book which aims to popularize physics by emphasizing conceptual ideas of physics and their interconnections, while avoiding mathematics entirely. The topic of this volume, "Colors, Light and Optical Illusions" is chosen as we face colors and light every waking minute of our lives, and we experience optical illusions much more often than we realize.